Amarillo (/ ˌæməˈrɪloʊ / [6] AM-ə-RIL-oh; Spanish for "yellow") is a city in the U.S. state of Texas and the county seat of Potter County. It is the 16th-most populous city in Texas and the most populous city in the Texas panhandle. [7] A portion of the city extends into Randall County. The estimated population of Amarillo was 200,393 as of April 1, 2020, comprising nearly half of the ...