Feb 26, 2024 · The largest vaccine safety study to date has identified two new, but very rare, side effects associated with covid-19 vaccines—transverse myelitis and acute disseminated encephalomyelitis. The Global Vaccine Data Network cohort study included 99 million vaccinated people from 10 sites across eight countries. Researchers compared the observed with expected rate for 13 neurological, blood, and ...

Jan 17, 2024 · Rheumatoid arthritis (RA) is one of the most common immune mediated inflammatory diseases. People with rheumatoid arthritis present with pain, swelling, and stiffness that typically affects symmetrically distributed small and large joints. Without effective treatment, significant joint damage, disability, and work loss develop, owing to chronic inflammation of the joint lining (synovium). Over ...

Nov 27, 2024 · Objective To compare the effectiveness of interventions for the management of long covid (post-covid condition). Design Living systematic review. Data sources Medline, Embase, CINAHL, PsycInfo, Allied and Complementary Medicine Database, and Cochrane Central Register of Controlled Trials from inception to December 2023. Eligibility criteria Trials that randomised adults (≥18 years) with long ...

Apr 10, 2024 · Survival. Survival following a diagnosis of heart failure is poor and is highly influenced by age. In the UK, survival approaches 80% at five years for people aged 45-64 but is closer to 20% at five years for those aged ≥85.7 Fortunately, survival rates have improved since 2000, particularly among younger patients.7 Although overall survival is an important outcome, it reflects the combined ...

Nov 18, 2021 · Objective To review the evidence on the effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission, and covid-19 mortality. Design Systematic review and meta-analysis. Data sources Medline, Embase, CINAHL, Biosis, Joanna Briggs, Global Health, and World Health Organization COVID-19 database (preprints). Eligibility criteria for study selection ...

May 30, 2022 · Objective To examine the effectiveness of behavioural weight management interventions for adults with obesity delivered in primary care. Design Systematic review and meta-analysis of randomised controlled trials. Eligibility criteria for selection of studies Randomised controlled trials of behavioural weight management interventions for adults with a body mass index ≥25 delivered in primary ...

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Jun 27, 2023 · Pain related diseases are the leading cause of disability and disease burden worldwide. 1 2 Chronic pain affects between a third and half of the population globally, 3 4 5 and high impact chronic pain—defined as pain experienced on most days or every day in the previous three months that causes restriction in at least one activity—has been found to affect 4.8% of the US adult population. 6 ...

Jan 24, 2023 · A summary of the management strategies recommended in the new 2022 NICE guidance on management of osteoarthrits, highlighting changes from the previous (2014) guidance

Severe pneumonia is associated with high mortality (short and long term), as well as pulmonary and extrapulmonary complications. Appropriate diagnosis and early initiation of adequate antimicrobial treatment for severe pneumonia are crucial in improving survival among critically ill patients. Identifying the underlying causative pathogen is also critical for antimicrobial stewardship. However ...