A nontreponemal test (NTT) is a blood test for diagnosis of infection with syphilis. Nontreponemal tests are an indirect method in that they detect biomarkers that are released during cellular damage that occurs from the syphilis spirochete .

2024年9月9日 · A presumptive diagnosis of syphilis requires use of two laboratory serologic tests: a nontreponemal test (i.e., Venereal Disease Research Laboratory [VDRL] or rapid plasma reagin [RPR] test) and a treponemal test (i.e., the T. pallidum passive particle agglutination [TP-PA] assay, various EIAs, chemiluminescence immunoassays [CIAs] and ...

Nontreponemal tests. Three types of nontreponemal tests are available in the United States: the rapid plasma reagin (RPR), the Venereal Disease Research Laboratory (VDRL) test, and the toluidine red unheated serum test. These tests usually react with immunoglobulin M and immunoglobulin G antibodies.

2024年2月6日 · Nontreponemal (lipoidal antigen) tests typically have been used as a screening test for syphilis, as a diagnostic test when patients have signs or symptoms suggestive of syphilis or have a known sexual contact, when assessing possible reinfections, and when monitoring treatment outcome .

The serological tests most commonly used to screen for the disease are the non-Treponemal and Treponemal tests. The non-Treponemal tests such as RPR or the VDRL test measure the hosts response to non-Treponemal antigens such as cardiolipin and lecithin released from the damaged host cells, as well as lipoprotein-like material released from the ...

In summary, nontreponemal tests are sensitive, cost-effective, and useful for screening and monitoring syphilis. However, they require confirmation with a treponemal test and can produce false-positive results. Treponemal tests are specific tests that directly detect antibodies against Treponema pallidum.

Serologic tests for syphilis are widely adopted using non-treponemal or treponemal tests by either the traditional or reverse algorithm and remain the gold standard in the diagnosis of syphilis patients. In addition, nucleic acid amplification assay is capable of detecting T. pallidum DNA in the samples from patients with syphilis. Notably, PCR ...

Nontreponemal tests include: Rapid plasma reagin (RPR) Venereal Disease Research Laboratory (VDRL) Toluidine Red Unheated Serum Test (TRUST) Mnemonic: Do not trust VDRL rapidly. Features of non treponemal tests: They are based upon the reactivity of serum from infected patients to a cardiolipin-cholesterol-lecithin antigen.

2020年9月29日 · Syphilis tests are available in two categories: treponemal tests (antibody tests to the organism itself, Treponema pallidum) and non-treponemal tests (such as RPR, which detects non-treponemal reagin antibodies; commonly seen with syphilis, but present in many other disease and non-disease states).

The most widely available non-treponemal tests are the microscopic Venereal Diseases Research Laboratory (VDRL) and the macroscopic rapid plasma reagin (RPR) tests. These tests detect anti-lipid immunoglobin M or G (IgM or IgG) antibodies.