2023年4月4日 · DoD IL4 overview. The Defense Information Systems Agency (DISA) is an agency of the US Department of Defense (DoD) that is responsible for developing and …

The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T h 0 cells) to T h 2 cells. Upon activation by IL-4, T h 2 cells subsequently produce additional IL-4 in …

STAT6 is so vital for the actions of IL-4 that Stat6-deficient mice phenocopy many of the defects observed with Il4- or Il4ra-deficient mice (e.g., related to Th2 differentiation and Ig class switch).

2024年12月25日 · IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway …

IL-4 plays important roles in a myriad of cellular events, making it difficult to study its effects, particularly in vivo, on any one system. Although this review focuses on its neurological …

2021年9月7日 · Interleukin-4 (IL-4) is a four-α-helical bundle type I cytokine with broad pleiotropic actions on multiple lineages. Major actions of IL-4 were initially discovered for B and T cells, …

IL4R is the human gene coding for IL-4Rα, the subunit which combines with either common gamma chain (γc, forming the type I IL4 receptor) or with IL-13Rα1 (forming the type II IL4 …

Interleukin-4 is a multifunctional cytokine that plays a critical role in the regulation of immune responses. Its effects depend upon binding to and signaling through a receptor complex …

2003年7月1日 · Acute expression of the IL4 gene by differentiated T H 2 cells is regulated by many positive and negative inducible transcription factors, such as nuclear factor of activated …

Higher levels of IL4, IL4Ra, and IL13Ra1 mRNA expression were detected in gastric than colorectal cancer, which, taking into account their association with tumor progression and …