As chlorpromazine is the most widely used broad-spectrum antipsychotic 'tran quillizer,' obtaining a thorough knowl e.dge of its in vivo metabolism is impera tive and may also aid in the …

The major routes of metabolism include hydroxylation, N-oxidation, sulfoxidation, demethylation, deamination and conjugation. There is little evidence supporting the development of metabolic …

2015年7月17日 · A single oral dose (120 mg/m2) of Chlorpromazine hydrochloride was administered to four healthy subjects and the blood levels of Chlorpromazine were determined …

2023年5月16日 · Chlorpromazine is extensively metabolized by the liver (CYP450 enzymes 1A2 and 2D6; it is a CYP3A4 substrate). It also undergoes metabolism in the kidney and GI tract. It …

The overall picture of the human metabolism of chlorpromazine as indicated by the urinary excretion products is that the compound undergoes demethylation, sulphoxida- tion, …

A study was carried out in 11 healthy young men to investigate the pharmacokinetics of chlorpromazine (CPZ) after a bolus intravenous (IV) dose (10 mg) and three single oral doses …

It is shown that chlorpromazine and its mono-and di-demethlated derivatives are hydroxylated and that these hydroxy compounds are conjugated mainly with glucuronic acid and, to a lesser …

A single oral dose (120mg/m 2) of chlorpromazine hydrochloride was administered to four healthy subjects and the blood levels of chlorpromazine were determined with time. Appropriate …

Chlorpromazine metabolism. IX. Pharmacokinetics of chlorpromazine following oral administration in man J Pharmacokinet Biopharm. 1978 Jun;6(3):187-96. doi: 10.1007/BF01312261. Authors …

Chlorpromazine, promazine and their demethylated products were shown to undergo metabolic N- and alpha-C-oxidation, to yield hydroxylamines and carboxylic acids, on incubation with …