Findings from the current study facilitated identification of novel putative cellular and molecular targets of arsenic’s teratogenicity, as well as understanding of the effects of prenatal arsenate exposure on cranial neural crest (NC) proliferation, survival and migration.

Prenatal arsenic exposure alters expression of REST/CoREST complex genes and associated microRNAs that create a regulatory loop to control differentiation of neural stem cells. Open in a new tab

Chronic exposure to arsenic (As) promotes skin carcinogenesis in humans and potentially disturbs resident stem cell dynamics, particularly during maternal and early life exposure. In the present study, we demonstrate how only prenatal arsenic exposure disturbs keratinocyte stem …

The main arsenic cell damage pathway is with p53, which dysregulation leads to apoptosis, proteotoxicity, inflammation, and proliferative signaling. 5. These pathways' disruption in the cell cycle causes cell cycle progression without an important mutation checkpoint, leading to numerous cancers. ... Prenatal arsenic exposure was inversely ...

2023年6月1日 · We found that prenatal arsenic exposure was associated with down-regulation of anti-oxidant defense genes, and up-regulation of apoptosis-related genes in neonates. We further showed that in utero arsenic exposure was associated with reduced thymic size and function in newborns and infants as well as reduced IL-7 levels in breastmilk [2, 40, 41 ...

2020年8月1日 · We investigated the impact of exclusive prenatal arsenic exposure on the inflammatory immune response and respiratory health after an adult influenza A virus (IAV) lung infection. C57BL/6J mice were exposed to 100 ppb sodium arsenite in utero, and subsequently infected with IAV (H1N1) after maturation to adulthood.

2025年1月1日 · Arsenic exposure during pregnancy impairs synapsis formation and homologous recombination-mediated repair of DSBs, resulting in fewer crossovers. Arsenic exposure during pregnancy activates the pachytene checkpoint and leads to a decrease in diplotene oocytes used to assemble primordial follicles.

2023年7月7日 · This study highlights significant long-term impacts of prenatal arsenic exposure on lung and immune cell function. These effects may contribute to the elevated risk of respiratory diseases associated with prenatal arsenic exposure in epidemiology studies and point to the need for more research into mechanisms driving these maintained responses.

2014年5月1日 · Prenatal arsenic exposure is associated with increased risk of disease in adulthood. This has led to considerable interest in arsenic’s ability to disrupt fetal programming. Many studies report that arsenic exposure alters DNA methylation in whole blood but these studies did not adjust for cell mixture.

We investigated the impact of in utero environmental arsenic exposure on immune development and function in newborns participating in a pregnancy cohort in New Hampshire, U.S., where arsenic levels have exceeded the current EPA maximum contaminant level of 10 μg/L.