How can only 25,000-30,000 protein-coding genes in humans produce the massive variety of proteins, cells, and tissues that exist in our bodies? The answer: alternative splicing. A critical finding ...

As a consequence, cells have evolved a 'gene-expression factory' that encompasses the routing of a nascent transcript through multimeric mRNA–protein complexes that mediate its splicing ...

Research into splicing mechanisms and patterns is essential for decerning fundamental biological principles, as well as clarifying the molecular basis of many diseases and developing new therapies. 2 ...

These proteins are involved in the process of mRNA splicing, which is a key step in mRNA metabolism. Put simply, it enables a cell to produce diverse mature mRNA molecules (and eventually proteins ...

The Steps of Protein Synthesis In prokaryotes ... and exons are joined together to form a mature mRNA molecule. The splicing process is essential for generating functional mRNA and producing ...