SLC25A1 drives citrate export from the mitochondria to the cytosol, where it fuels acetyl-CoA synthesis by ATP citrate lyase (ACLY). This acetyl-CoA supply sustains FSP1 acetylation and prevents its ...

MANILA, Philippines — The Commission on Audit (COA) has called out the Philippine Atmospheric, Geophysical and Astronomical Services Administration (PAGASA) over P256.07 million worth of ...

Spanish National Research Council (CSIC), Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN), Jose Antonio Nováis 6 28040, Madrid, Spain ...

In this important work, Lodhiya et al. provide evidence that excessive ATP underlies the killing of the model organism Mycobacterium smegmatis by two mechanistically-distinct antibiotics. The data are ...

Here, we examined the effect of different carbon sources that are involved in the major metabolic pathways of acetyl-CoA synthesis on myocardial infarction and found that elevation of acetyl-CoA by ...

When content of acetyl-CoA was elevated due to increased β-oxidation or impaired glycolysis reduced the oxaloacetate derived from anaplerosis, ketogenesis will strengthen as consequence. Another ...

Metabolic control of histone acetylation is predominantly achieved through the acetyl group donor acetyl-CoA (14). In addition, histone deacetylation by a family of sirtuin histone deacetylases is ...

We see the seven stones of the Molecular Systems Biology cover as a visual allegory for Aristotle's visionary thought: The whole is greater than the sum of its parts.