Here’s a list of the leading Big Bang Theory cast and actors who played them. The Big Bang Theory ran for over a decade, ...

As many fans surely remember, in season 4 of the comedy The Big Bang Theory, Mrs. Fowler was played by Annie O'Donnell while appearing through a Skype video call while chatting with Amy.

Many of the characters who appeared in The Big Bang Theory only for a cameo helped ... a few of the reasons why major guest appearances played a key role in the overall development of the show.