Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its ...

Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its ...

Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its frontline defenders – T cells – lose their ability to function effectively.

Prolonged illnesses, such as cancer and persistent infections, can fatigue the immune system, causing its frontline defenders, T cells, to lose their ability to act efficiently. The Peter Doherty ...

CD8 + T cell exhaustion is defined by a unique transcriptional and epigenetic profile that is important to understand for the generation of immunotherapies to treat cancer. Research now shows how ...

Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the way for improved immunotherapies.

The response of PBMC in space shares T-cell exhaustion features, likely initiated by microgravity than by infection. Consequences of mitochondria dysfunction include immune dysregulation and prolonged ...

The malfunctioning mitochondria seem to poison the immune cells, explains Yosuke Togashi, a pulmonary physician and ...

One such challenge is the lack of long-term persistence of CD28 based CAR T-cells in patients. Although, CD28 based CAR T-cells elicit a robust acute anti-tumor response, they are more prone to early ...