近日，美国得克萨斯大学西南医学中心Yunsun Nam团队揭示了癌症相关突变如何通过改变METTL3-METTL14复合体对RNA甲基化（m6A）的特异性来促进肿瘤发生。研究发现，METTL14的R298P突变能够改变m6A的序列偏好，优先修饰含有GGAU ...

A new study published in Advanced Science has revealed how curcumin, a bioactive compound found in Curcuma aromatica (Yujin), ...

癫痫是一种严重的神经系统疾病，反复发作不仅会导致神经元损伤，还会广泛激活脑内胶质细胞，引发局部免疫应答，释放促炎因子，从而加重病情，形成恶性循环。中医药自古以来便采用“白金丸”治疗癫痫，其中，郁金的主要药效活性成分姜黄素近年来被发现可能通过调节中枢神 ...

N6-methyladenosine (m6A) is the most abundant and well-studied RNA modification in eukaryotic cells. This modification is known to be involved in the regulation of various molecular mechanisms ...

临床意义和挑战：m6A 作为妇科疾病的生物标志物和治疗靶点的潜力是显而易见的，但其调控机制的复杂性以及在不同病理背景下对其作用的全面理解的需求，给临床应用带来了挑战。 表观转录组学是指对包括 mRNAs 和非编码 RNAs 在内的多种 RNA 分子进行动态可逆 ...

High levels of fat mass and obesity-associated protein (FTO) have been linked to increased tumor growth and resistance to immunotherapy. In a study ...

直接RNA测序（DRS）技术 ... CXCL10 mRNA的稳定性通过YTHDF1介导的m6A位点识别维持。 pum6a不仅扩展了m 6 Anet的功能，还通过整合电信号和碱基配对特征 ...

2021 年，一篇题为“Small RNAs are modified with N - glycans and displayed on the surface of living cells”的论文在 Cell 期刊上发表，首次向科学界揭示了糖基化 RNA （GlycoRNA）的存在。自此，围绕 RNA 糖基化的相关研究迅速成为热点，在标记技术、监测方法以及生物功能探究等方面不断取得新的突破， ...

Objective Fat mass and obesity-associated protein (FTO), an eraser of N 6-methyadenosine (m6A), plays oncogenic roles in various cancers. However, its role in hepatocellular carcinoma (HCC) is unclear ...

N6-Methyladenosine (m6A) affects the fate of modified RNA molecules and is involved in tumor progression. Different webservers were used in our research to investigate the mRNA transcription and ...