Department of Chemistry, Faculty of Philosophy, Science and Letters at Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-901, São Paulo, Brazil ...

SLC25A1 drives citrate export from the mitochondria to the cytosol, where it fuels acetyl-CoA synthesis by ATP citrate lyase (ACLY). This acetyl-CoA supply sustains FSP1 acetylation and prevents its ...

Aromatase is an enzyme that converts testosterone to estradiol, a type of estrogen. One study found that taking an estrogen blocker called an aromatase inhibitor while on testosterone therapy reduced ...

Prompts are the pieces of text you enter to instruct the AI model what to generate. To some it is an arcane art, and there are many opinions and mystic invocations floating around. Here we won't go ...

Custom workflows allow you to design node graphs in ComfyUI and run them from Krita. Images, layers, selections and masks can be exchanged, and important parameters can be exposed. Most of the plugin ...

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China Department of Medicinal Chemistry, School ...

Quercetin is a flavonoid present in many fruits, vegetables, and grains, recognized for its antioxidant and anti-inflammatory properties. Studies have explored the possibility of this nutrient ...

Clinical trials are now underway to test ACLY inhibitors for treating various cancers and metabolic disorders. A new target for anti-ageing interventions? Could targeting ACLY be a way to slow ...

These next-generation STAT6 inhibitors demonstrate excellent oral bioavailability, cell permeability, and metabolic stability, and do not target STAT6 for degradation. DeepCure expects to select a ...