SLC25A1 drives citrate export from the mitochondria to the cytosol, where it fuels acetyl-CoA synthesis by ATP citrate lyase (ACLY). This acetyl-CoA supply sustains FSP1 acetylation and prevents its ...

Additionally, PPARγ is identified as a transcription factor that regulates ACLY expression (35). SREBP2, a key transcription factor regulating ... ROS significantly increases PD-L1 mRNA levels by ...

However, the safety and efficacy of IL-13 inhibitors as a potent biologic for AD remain elusive. Objective: To assess the efficacy and safety of IL-13 inhibitors in moderate to severe AD. Method: ...

Department of Chemistry, Faculty of Philosophy, Science and Letters at Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-901, São Paulo, Brazil ...

Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K.

On a population level, the effects of PPI are more prominent than the effects of antibiotics or other commonly used drugs. Proton pump inhibitors (PPI) use is associated with increased risk of enteric ...