The response of PBMC in space shares T-cell exhaustion features, likely initiated by microgravity than by infection ... As shown in Figure 2, among the top dysregulated pathways are mitochondria ...

Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its frontline defenders—T cells—lose their ability to function effectively.

CD8 + T cell exhaustion is defined by a unique transcriptional and epigenetic profile that is important to understand for the generation of immunotherapies to treat cancer. Research now shows how ...

T-cell exhaustion, characterized by the overexpression of immune checkpoint molecules, contributes to osteosarcoma progression and immune evasion. Although targeting these inhibitory pathways has ...

Data from clinical studies suggest that complications of trauma are associated with immunosuppressive purinergic responses and elements of CD8 T cell exhaustion, characterised by increases in ...

1Department of Obstetrics and Gynecology, Peking University Third Hospital, China 2Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China. 3Biobank, Peking ...

Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its frontline defenders - T cells - lose their ability to function effectively. The ...

a state called stem cell exhaustion. (3) These observations support the stem cell theory of aging, which suggests that aging results from the inability of tissue-specific stem cells to replenish ...

Copyright: © 2025 Elsevier Ltd. Published by Elsevier Ltd. CAR T-cell therapies have revolutionised treatment of many diseases, but their expense means many patients ...