Where genes are associated with CD and UC, the p-values are given from the index gene discovery study; this is CD for all the genes presented here. * Colonic CD only. ‡ Early-onset disease ...

molbio.mgh.harvard.edu Studies of the genetics underlying inflammatory bowel diseases have increased our understanding of the pathways involved in both ulcerative colitis and Crohn's disease and ...

Crohn's disease and ulcerative colitis are idiopathic, chronic, relapsing, inflammatory conditions that are immunologically mediated. Although their exact etiologies remain uncertain, results from ...

Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel ...

Inflammatory bowel disease (IBD) is a group of chronic disorders that cause relapsing inflammation in the gastrointestinal tract and comprise three major subgroups of Crohn's disease (CD), ulcerative ...

Oxidative stress, caused by an imbalance between reactive oxygen species (ROS) and antioxidant defenses, plays a central role ...

Notably, the authors highlight the promising results of FMT in inducing remission in ulcerative colitis, as supported by recent clinical trials (1).The second review, "Exploring the role of IL-1β in ...

Tremfya could become the first IL-23 inhibitor with fully subcutaneous induction and maintenance options in the treatment of ...

Inflammatory bowel disease (IBD) is a term that encompasses two chronic diseases of the gastrointestinal tract—ulcerative colitis and Crohn's disease. Symptoms of both forms of IBD overlap and include ...

Several therapeutic advances have been achieved over the past two decades for inflammatory bowel disease (IBD). The expanding therapeutic armamentarium and the increasingly ambitious treatment targets ...