The past decade has seen significant advances in our understanding of skeletal homeostasis and the mechanisms that mediate the loss of bone integrity in disease. Recent breakthroughs have arisen ...

Weifang Key Laboratory of Respiratory Tract Pathogens and Drug Therapy, School of Life Science and Technology, Shandong Second Medical University, Weifang 261000, P. R. China ...

Researchers studying mesenchymal stem cells (MSCs) face significant challenges with traditional endpoint assays that provide only limited snapshots of the differentiation process. The inability to ...

We then used our model to explore how commonly applied therapies such as bisphosphonates (e.g., zoledronic acid) impact osteocyte network formation. Therapeutically, zoledronic acid is frequently used ...

Most bones in mammals display a limited capacity for natural large-scale repair. The ribs are a notable exception, yet the source of their remarkable regenerative ability remains unknown. Here, we ...

Bone is a rigid connective tissue composed mainly of organic components (90% type I collagen, the rest other non-collagenous structural proteins and cells) and inorganic minerals (mostly calcium ...