The heart drug digoxin could potentially be combined with existing cancer therapies to prevent the spread of tumors, an early ...

The study design comprised measuring the effect of the cardiotonic agent digoxin (a widely used Na+/K+ ATPase inhibitor) in reducing the size of circulating tumor cells clusters, i.e. aggregates ...

encouraging larger follow-up studies with refined Na+/K+ ATPase inhibitors and that include clinical outcome endpoints.” Certain tumor types do not remain at their point of origin but spread ...

Windtree Therapeutics, Inc. (NasdaqCM: WINT) showcased encouraging results from the Phase 2b SEISMiC study of istaroxime, its novel investigational therapy for early cardiogenic shock, at the ...

HSP90 inhibitors have also been shown to induce apoptosis by indirectly inhibiting Akt. The FDA-approved cardiac glycoside drugs digoxin, digitoxin, and ouabain can mediate the elimination of ...

However, TGF-β can also positively impact pulmonary edema. Intriguingly, TGF-β was proposed to increase the function of ENaC, via enhancing the expression of Na+/K+-ATPase α1- and β1-subunits (134). β ...

We are investigating the physiology of CatSper Ca2+ channels, sNHE Na+/H+ exchangers, Slo3 K+ channels, Hv1 voltage-gated H+ channels, and the plasma membrane Ca2+-ATPase PMCA4. In particular, we want ...

This important manuscript proposes a new strategy for the identification of new mechanisms of drug resistance based on SAturated Transposon Analysis in Yeast (SATAY), a powerful transposon sequencing ...

1 Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia 2 Neuroscience Research Australia & Prince of Wales Clinical School, University of New South Wales, ...

Unconventional Computing Laboratory, University of the West of England, Bristol BS16 1QY, U.K.