The linear sequence of amino acids within a protein is considered the primary structure of the protein. Proteins are built from a set of only twenty amino acids, each of which has a unique side chain.

ESM3 can reason over protein sequence, structure, and function, by representing each of these through alphabets of discrete tokens that can be combined in a generative language model. This ...

Guided by a multimodal generative language model called ESM3, Thomas Hayes and colleagues generated and synthesized a previously unknown bright ...

In biology, the binding of cellular proteins to molecules called ligands produces a myriad of functions essential for life ...