It’s a new way to create “bi-paternal” mice that can survive to adulthood—but human applications are still a long way off.

to knockout and characterize all protein-coding genes in the mouse genome. Knocking out the activity of a gene provides valuable clues about what that gene normally does. However, creating and ...

Both gene knockout and knock-in models are powerful tools widely used in biomedical research to gain important insights into ...

“Having a complete knockout, you’ll have much stronger phenotypes compared to other techniques,” said Jan Carette, a Stanford University professor who was not involved in the current study, but who ...

This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in ...

Synthego, a leading genome engineering solutions company, today announced the launch of the Gene Knockout Kit v2. This is the only product that leverages a novel bioinformatics- powered multi-guide ...

Researchers find that certain antioxidant enzymes, called selenoproteins, significantly contribute to fighting cell aging. The team used a gene knockout mouse model to help them study the effects of ...

Scientists from the Cancer Dependency Map (DepMap) at the Broad Institute of MIT and Harvard and Columbia University have ...

Australian researchers have successfully introduced an improved version of Cas12a gene-editing enzyme in mice.

To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene of interest. This may be done by deleting portions of the gene's DNA sequence to make it nonfunctional ...