Despite promising Phase 3 results, safety concerns, namely liver injury, have impacted Agios stock and could affect Pyrukund's approval and market adoption. Read the full report here.

succinate dehydrogenase; IDH, isocitrate dehydrogenase; TCA, Tricarboxylic acid; HDAC, histone deacetylase; Kla, lactylation. However, the specific mechanisms underlying lactate uptake and utilization ...

Known enzymes involved in this process include malic enzyme, glucose-6-phosphate dehydrogenase and 6-phosphogluconic dehydrogenase from the phosphate pentose pathway and isocitrate dehydrogenase (Hao ...