Isocitrate dehydrogenase (IDH) is an oncogene, and the expression of a mutated IDH promotes cell proliferation and inhibits cell differentiation. IDH exists in three different isoforms, whose mutation ...

Despite promising Phase 3 results, safety concerns, namely liver injury, have impacted Agios stock and could affect Pyrukund's approval and market adoption. Read the full report here.

Medscape, January 16, 2025 Fast Five Quiz: IDH Mutations in Brain Cancer Do you understand the nuances of isocitrate dehydrogenase biomarkers in brain cancer? Check your knowledge with this quick ...

Genes involved in export of lipooligosaccharides, heme (used in membrane-bound succinate dehydrogenase), and other components related to the cell membrane or extracellular structures were detected ...

Copyright: © 2025 The Author(s). Published by Elsevier Ltd.

Adolescent Trauma Outcomes Similar at Ped, Adult Centers Adolescent trauma care at pediatric and adult centers showed no significant difference in mortality rates, suggesting that both settings ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

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