Ion channels are integral membrane protein assemblies that modulate the flow of ions into and out of a cell or organelle, leading to generation of electrical signals. Opening (gating) of ion ...

Therapeutic benefits of TRPV4 inhibition have, therefore, to be carefully weighed against potential adverse ... permeability or the hemodynamic response associated with hypoxemia and HAPE (4). Recent ...

While ion channels have been implicated in maintaining cellular homeostasis, their cell surface localization often places them among the first few molecules to sense external cues. Mechanosensitive ...

Pharmacological or genetic inhibition of acid-sensing ion channel 3 impeded the development of LPC16:0-induced chronic hyperalgesia. Darapladib and antioxidants could effectively alleviate the ...

Jazz Pharmaceuticals has agreed another pipeline-building deal, this time paying $10 million upfront for rights to a KRAS inhibitor programme from UK biotech Redx Pharma, continuing a move into ...

Meet suzetrigine, a non-opioid that promises to avoid addiction risk. But some experts say it can't replace opioids ...

New research sheds light on how ketamine affects the brain by targeting a specific NMDA receptor subtype, GluN1-2B-2D.

The drugs most frequently used by these patients were diuretics, converting enzyme inhibitors, calcium channel blockers (CCB), lipid-lowering agents, and salicylates. Eczema was significantly ...

drowsiness or dizziness Angiotensin II receptor blockers These may be used to treat heart failure or after a heart attack. dizziness, headache, fatigue, and others Calcium channel blockers These ...