A team from Baylor College of Medicine and Texas Children's Cancer Center led the study, which tested chimeric antigen receptor (CAR) T cells enhanced with the protein interleukin-15 (IL-15).

Interleukin 15 (IL-15), also referred to as IL15 or IL-15, is a cytokine that shares structural similarities with IL-2. Like IL-2, IL-15 signals through the IL-2/IL-15 beta chain (CD122 ...

Evaluation of: Waldmann TA, Conlon KC, Stewart DM et al. Phase 1 trial of IL-15 trans presentation blockade using humanized Mik-β-1 mAb in patients with T-cell large granular lymphocytic leukemia.

Hu-Mikβ1 is a humanized antibody to the IL-2/IL-15Rβ receptor and was shown to block IL-2- and IL-15-driven cell proliferation in preclinical models and patient leukemic cells. Hu-Mikβ1 was ...