In its role in recruitment of histone methyltransferase activity, it can act as a tumor suppressor by activating transcription of antiproliferative target genes, such as those encoding a cyclin ...

In this context, a comment by Chen et al. provides valuable insights into the catalytic and noncatalytic functions of the histone methyltransferase SETD2, a protein responsible for histone H3 ...

Laboratory for Drug Design and Synthesis, Department of Pharmaceutical Sciences and Natural Products, School of Pharmaceutical Sciences, Central University of Punjab, Bathinda 151 401, India ...

National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States ...

Lysine methyltransferases are important components of the post-translational histone methylation modification pathway. Lysine methyltransferase 2C (KMT2C), also known as MLL3, is a member of the ...

Positive-feedback loops and cooperativity among chromatin-modifying complexes are crucial for the propagation of histone marks. The nuclear architecture and long-range interactions are likely to ...

The histone lysine methyltransferase DOT1L (DOT1-like histone lysine methyltransferase) is responsible for the epigenetic regulation of gene expression through specific methylation of lysine79 residue ...