These useful findings assigned a novel functional implication of histone acylation, crotonylation. Although the mechanistic insights have been provided in great detail regarding the role of the YEATS2 ...

The chromatin-bound proteome of embryonic stem cells transitioning to 2C-like cells uncovers chromatin regulators involved in heterochromatin formation.

The following is a summary of “Histone Modifications and DNA Methylation in Psoriasis: A Cellular Perspective,” published in ...

Background: Lactylation plays an essential role in pancreatic cancer, but the precise role of lactylated histone in the diagnosis and prognosis of pancreatic cancer remains to be further clarified.

Japan's epigenetics market is evolving rapidly, with a strong emphasis on AI-driven research and personalized medicine, addressing complex diseases t ...

This effect was specific to stimulation by uric acid and was exerted at the level of gene transcription. Epigenetic reprogramming at the level of histone methylation by uric acid was involved in this ...

Here, we sought to identify specific histone demethylases that are involved and delineate the underlying mechanisms. Conclusions These findings indicate that knockdown of Kdm6b in chondrocytes leads ...

Department of Chemistry, King’s College London, Britannia House, 7 Trinity Street, London SE1 1DB, U.K.

The numbers of the principal regulatory elements present in insulin promoters are listed. Given the complexity and uncertainty of predicting the transcriptional outcome of mutations within ...