with histone acetylation playing a crucial role. Studies in numerous HD models have shown that mutant huntingtin alters histone acetyltransferase activity, and indicate that aberrant activity of ...

Previous studies have shown that neuronal histone acetylation is reduced in mouse models of RSTS. Conclusions The authors' results extend to humans the seminal observations in RSTS mouse models and ...

These useful findings assigned a novel functional implication of histone acylation, crotonylation. Although the mechanistic insights have been provided in great detail regarding the role of the YEATS2 ...

Methods FLS were purified from patients with RA and CD14 + human monocyte-derived macrophages were obtained from healthy donors. RNA-sequencing, histone 3 lysine 27 acetylation (H3K27ac), chromatin ...

Indeed, several drugs targeting histone modifications are in clinical use or undergoing clinical trials. Acyl-lysine histone modifications (e.g. methylation, acetylation, and crotonylation) have ...

Specifically, while considerable attention has been given to histone methylation and acetylation in the context of embryo implantation and placentation, further investigations are required to fully ...

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

The chromatin-bound proteome of embryonic stem cells transitioning to 2C-like cells uncovers chromatin regulators involved in heterochromatin formation.

Here, we sought to identify specific histone demethylases that are involved and delineate the underlying mechanisms. Conclusions These findings indicate that knockdown of Kdm6b in chondrocytes leads ...

Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen 518000, China ...