Systemic sclerosis causes the skin to tighten and harden resulting in a potentially fatal autoimmune condition that is associated with lung fibrosis and kidney disease. University of Michigan ...

Since only a few PI5P4K regulators were known, the research team screened 29 other potential regulators and found two—core ...

It has long been understood that the Hippo pathway plays a critical role in the development of a wide range of diseases. Although once seen as an elusive pathway, emerging novel data and research ...

Sujata Rao, MD, Chief Medical Officer of Insilico Medicine As a potent pan-TEAD inhibitor, ISM6331 was developed to effectively restore the balance of the Hippo pathway and prevent the ...

A phase 3 trial of lanifibranor, a pan-PPAR agonist, in patients with MASH and liver fibrosis is ongoing. But with the 96.6 ...

Two seemingly disparate signaling pathways -- one that controls organ size in fruit ... to restrict cell proliferation and control heart size. Wild-type (left) and Hippo mutant (right) neonate mouse ...

The lab reported in the journal Science that a gene pathway called Hippo inhibits cardiac muscle regeneration during development. View the Science Journal article. Our lab is currently working to ...