Nat Clin Pract Urol. 2007;4(6):321-332. Blockade of 5α-reductase with drugs such as finasteride does not seem to induce large morphological changes in HGPIN, unlike other forms of androgen ...

High-grade prostatic intraepithelial neoplasia (HGPIN) is the most likely precursor of prostatic adenocarcinoma according to virtually all available evidence. This lesion is characterized by ...

5Department of Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. 6Department of Pharmaco-Therapy, -Epidemiology and- Economy, ...

More information: Vvax001, a therapeutic vaccine for patients with HPV16-positive high-grade cervical intraepithelial neoplasia: a Phase II trial, Clinical Cancer Research (2025). DOI: 10. ...

Early diagnosis and treatment of these lesions can prevent the development of carcinoma, especially raising women's awareness of the importance of the PAP test for the purpose of detecting this ...

“Our findings demonstrate that the therapeutic vaccine Vvax001 is safe, well-tolerated, and effective in eradicating HPV16-associated CIN3 lesions and clearing the underlying persistent HPV16 ...

Outcome The primary evaluation was the detection rate of cervical intraepithelial neoplasia grade 2 or worse (CIN2 ... For example, the most recent assessment found that there are annually about 160 ...

This material on this page is ©2025 American Society of Clinical Oncology, all rights reserved. Licensing available upon request. For more information, please ...