Acute and chronic liver injury models were performed in wild type and Trem-2-/-mice. Primary liver cells from both genotypes of mice were isolated for in vitro experiments. Results TREM-2 was ...

The liver is composed of parenchymal cells (hepatocytes) and non-parenchymal cells, with liver non-parenchymal cells mainly encompassing LSEC, hepatic stellate cells, Kupffer cells, and immune cells.

Hepatic macrophages are a remarkably heterogeneous population consisting of self-renewing tissue-resident phagocytes, termed Kupffer cells (KCs), and recruited macrophages derived from peritoneal ...

The different mechanisms by which cholestatic and parenchymal liver disease can lead to reduced bone mass, the prevalence of osteopenia and osteoporosis in patients with early and advanced liver ...

Discover how integrating advanced imaging, digital pathology, and molecular analysis, can refine fibrosis staging and ...

Liver cancer is uncommon in the United States, but it is common worldwide due to risk factors such as chronic hepatitis B and C infections and exposure to aflatoxin (toxins produced by a certain ...

The liver, located in the upper right side of the abdomen, is the body’s largest organ and one of the most important. The liver performs hundreds of vital functions, including converting ...

Elevated liver enzymes can occur for many reasons. Most often, elevated liver enzymes are temporary and resolve on their own without treatment. Occasionally, elevated liver enzymes require additional ...

Treatment did not produce any signs of improvement in liver function; however, histological examination revealed an improvement in portal inflammation, parenchymal alterations and necrosis.

This important study provides insights into the physiological role of RIPK1 in liver physiology, particularly during short-term fasting. The discovery that RIPK1 deficiency sensitizes the liver to ...

These updated guidelines on the management of abnormal liver blood tests have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) ...