Researchers discovered a previously unknown mechanism that may drive tissue damage and a new target for drug discovery.

Our immune system is armed with an array of defenses designed to detect and eliminate harmful threats. One of its most ...

Mass General Brigham researchers discovered a previously unknown mechanism that may drive tissue damage and a new target for drug discovery ...

Researchers found that bioengineered CAR-T cells when mixed with other immune cells can "donate" proteins, suggesting ...

These cells were found to promote airway inflammation through the characteristic effector molecule Granzyme K (GZMK), which is a serine protease involved in inflammatory pathway activation.

Accordingly, the researchers engineered cyclic peptides—small amino acid chains—to respond only when they encounter two specific types of enzymes, proteases called granzyme B (secreted by the ...

Mild cognitive impairment is linked to blood vessel dysfunction in the brain's temporal lobes - the seat of memory - according to a new USC-led study. The findings, seen in people with and without ...

Inflammation is a biological response to harmful stimuli, such as pathogens, damaged cells or irradiation. It is a protective attempt by the organism to remove injurious stimuli and to initiate ...

众所周知，通过单细胞测序、细胞聚类分析，可以快速的找到感兴趣的细胞亚群和与疾病相关的目标基因。但是，接下来，还需要在蛋白质的层面对从测序层面得到的结果进行验证。例如通过流式细胞技术和多重免疫染色技术等对特定细胞亚群进行表型和功能 ...

This patent application pertains to macrocyclic peptides and their radiolabeled derivatives, generally represented by Formula I. These compounds exhibit selective binding to Granzyme B (GzmB) and hold ...