This study presents a useful finding that targeting amino acid metabolism can overcome Trastuzumab resistance in HER2+ breast cancer. The evidence supporting the claims of the authors is solid and the ...

An improved understanding of the metabolic pathways dysregulated in CLE may lead to novel treatment options, biomarkers and insights into disease pathogenesis. The objective was to compare metabolomic ...

Metabolic disorders such as iron overload, glycolysis, insulin resistance, lipid dysregulation, and glutaminolysis are found to induce liver senescence and ferroptosis, which are hot topics in the ...

Several major pathways for the utilization of carbohydrates ... From the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, and the departments of medicine ...

Furthermore, ML385, an NRF2 inhibitor, reversed these effects of EUG. The present study suggested that EUG exerted protective effects on pancreatic β cells in T1DM by attenuating apoptosis and ...

From the GO analysis, we screened the upregulated differentially expressed genes and identified key pathways, including mitophagy, autophagy, ferroptosis, apoptosis, nonalcoholic fatty liver disease ...

The MEP pathway is an essential part of the energy metabolism of several bacteria, including the hospital germ Pseudomonas aeruginosa. If the MEP pathway in bacteria is blocked, for example by a ...

Key Laboratory of Cryogenics Science and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Laboratory of Controllable Preparation and Application of Nanomaterials, ...

Moreover, we demonstrated that LPS decreases glucose levels and increases progesterone levels in the CL. Conclusion: These findings suggest that LPS modulates key metabolic pathways in the CL, ...