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FLAD1拷贝数扩增通过脂质代谢促进三阴性乳腺癌的进展
拷贝数改变在三阴性乳腺癌患者中经常发生。在这里,作者确定了FAD合成酶(FLAD1)在TNBC中作用的拷贝数扩增,并从机制上证明了这种扩增通过FLAD1/LSD1/SREBP1轴增加脂质代谢来驱动肿瘤发生。
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