(A-B) Knockdown of SLC7A11 (A) and GPX4 (B) induced increased lipid peroxidation (BODIPY-C11) in JIMT1. (C-D) Treatment with erastin, RSL3 and cysteine starvation for 12 hours induced lipid ...

Table 2 Small molecule compounds targeting SLC7A11. Although erastin demonstrates a potent inhibitory effect on Systems Xc-, its practical application in vivo is significantly hindered by its limited ...

All other chemicals were supplied by Sigma-Aldrich (Buchs, Switzerland), except where indicated. C2C12 murine myoblasts (American Type Culture Collection [ATCC], USA) were grown in confluency in ...