Aim: We evaluated a novel treatment for obesity-related renal, an ATP-citrate lyase (ACL) inhibitor ... could decrease the levels of serum lipid and renal lipogenic enzymes acetyl-CoA carboxylase (ACC ...

The crystal structure of pseudouridine synthase I from Escherichia coli, which, for example, modifies positions 38, 39 and/or 40 in tRNA, reveals a dimeric protein that contains two positively ...

With the approval of the soluble guanylate cyclase stimulator riociguat, an additional drug class has become available targeting a distinct molecular target in the same pathway as PDE5 inhibitors.

Activities of the respiratory chain complexes were assayed by spectrophotometric methods as described previously.12 The mitochondrial matrix enzyme citrate synthase served as an internal control. DNA ...

Molecular conformation is any spatial arrangement ... probe the transmembrane signaling mechanism of CitA, a paradigmatic citrate sensing membrane embedded histidine kinase. Enhanced sampling ...

An artificial intelligence model has created a new protein that researchers say would have taken 500 million years to evolve in nature — if nature were capable of producing such a thing.

Examples include magnesium citrate and magnesium glycinate. They may benefit health in a number of ways, from improving blood sugar and blood pressure to reducing anxiety. Magnesium is a mineral ...

With the recent surge in popularity of weight loss drugs like Ozempic, altogether called GLP-1s, there has been renewed scientific interest in understanding how our bodies regulate muscle growth.

State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province ...

State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, School of Life Sciences, Hubei University, Wuhan 430062, PR China State Key Laboratory of Biocatalysis and ...