We aimed to evaluate the role of an ATP-citrate lyase inhibitor as a novel treatment for obesity-related nephropathy ... which were amplified by SYBR Green and the Roche LightCycler 480 system. In a ...

SLC25A1 drives citrate export from the mitochondria to the cytosol, where it fuels acetyl-CoA synthesis by ATP citrate lyase (ACLY). This acetyl-CoA supply sustains FSP1 acetylation and prevents its ...

Moreover, the role of specific amino acids in CYP17A1 has been investigated, particularly Asparagine 202, which appears to influence substrate preference and the efficiency of the lyase reaction.

Magnesium is an essential mineral involved in more than 300 reactions in the body. Most plant-based foods contain magnesium. Still, most Americans do not meet magnesium requirements through food ...

Department of Cell & Molecular Biology, Uppsala University, Biomedical Center, SE-751 24 Uppsala, Sweden ...

Allergies are an immune system reaction to substances called allergens. The cause a range of symptoms from a stuffy nose to itchy eyes to difficulty breathing. How long allergies last varies based on ...

Sarah Vine and Andrew Pierce bring their own no-holds-barred opinions, insights and reaction (clue is in the title) to the biggest stories of the week. New episodes every Wednesday, wherever you ...

Raptors win their fifth road game of the season.

Reactions to a recent immunization (vaccine) Most are reactions at the shot site (such as pain, swelling, redness) General reactions (such as a fever or being fussy) may also occur ...

Additionally, genes involved in surface adhesion, the import of metallic cations found in Fe-bearing minerals, and use of molecular hydrogen, a product of serpentinization reactions between water and ...

This reduction can result in citrate-induced hypocalcemia, commonly referred to as citrate-related reactions. These reactions represent the predominant adverse event linked to PBPC apheresis, with ...