In the first instalment of a series to mark the 10th anniversary of the Future Science Prize, Holly Chik and Shen Xinmei look ...

The eccDNAs currently studied in this paper are mainly large, copy number–amplified extrachromosomal circular DNA. EccDNAs are widely present in human tumor tissues and tumor cell lines, where they ...

Hirt covalently closed circular DNA extraction and Taq-man probe qRT–PCR For HBV cccDNA extraction, we used the previously described modified Hirt method (Cheng et al., 2021). In brief, the cells were ...

Researchers say if their results are confirmed through further study they are optimistic the approach could be used to treat chronic infections for the first time.

Recent research reveals that DNA and RNA epigenetics, previously studied as independent systems, actually function as a complementary regulatory network. This dual mechanism enables precise gene ...

Cancer cells store genes in circular pieces of DNA, known as extrachromosomal DNA or ecDNA, that defy the laws of genetics. Scientists have known about ecDNA since the 1960s, but it was thought to be ...

Serum HBV RNA levels quantified by using a new automated prototype assay significantly correlated with intrahepatic covalently closed circular DNA (cccDNA ... In HBeAg(−) patients, the predominant ...

15, 2025 — While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows.

BACKGROUND: Circular RNAs derived from both nuclear and mitochondrial genomes are identified in animal cells.

Circular mammoth-bone structure ... or some other purpose is yet unclear. But now, a new DNA study of 39 bone samples from 30 mammoths from the Kostenki 11 site is offering new clues about ...