Adenosine Deaminase 2 Deficiency (DADA2) is a rare genetic disorder that has gained attention for its association with a variety of clinical manifestations, particularly systemic vasculitis.

Adenosine deaminase (ADA) deficiency is a genetic disorder that leads to severe combined immunodeficiency (SCID), a condition where the immune system is severely compromised. This deficiency ...

As childhood PAN is a phenocopy of adenosine deaminase 2 with a different management strategy, whole-exome sequencing was performed, which revealed a pathogenic variant in ADA2 gene. The child was ...

The clinical features of MAS overlap with those of active sJIA, complicating early diagnosis and treatment. We evaluated adenosine deaminase 2 (ADA2), a protein of unknown function released ...

Orchard Therapeutics' Strimvelis for the vanishingly rare "bubble boy" disease adenosine deaminase deficiency (ADA-SCID) – originally developed by GlaxoSmithKline – reached the market in 2016 ...

Accumulating evidence has indicated that a hypo-editing (editing deficiency) phenotype is found in brain tumours and tumour tissues ... which is catalysed by the double stranded RNA (dsRNA) specific ...

Approximately 20% of all cases of SCID arise from an autosomal recessive deficiency of adenosine deaminase (ADA), a ubiquitously expressed “housekeeping” enzyme that is required for the degradation of ...

Leg cramping at night is thought to be associated with magnesium deficiency, and magnesium ... Magnesium has a hand in adenosine triphosphate synthesis, says Wagner, which is produced in the ...

This immunomodulating pathway in Teff mediates clinically important responses to regulatory T cell (Treg) suppression and inflammatory mediators, such as prostaglandins (PGs), adrenergic stimuli, ...

Vitamin B12 Deficiency Symptoms: Vitamin B12 is an essential nutrient that plays a vital role in your overall health. It is crucial for red blood cell production, DNA synthesis, and the proper ...

Most B cells produced in the bone marrow have some level of autoreactivity. Despite efforts of central tolerance to eliminate these cells, many escape to periphery, where in healthy individuals, they ...

Vitamin deficiency due to hair loss (alopecia) may occur with deficiencies in vitamins B, D, C, and E, as well as with certain minerals like iron, selenium, and zinc. The complex roles of nutritional ...