It was found that male mice with no ability to produce the MC2 protein were unable to form the connection between the tail and the head of the sperm and the mice became infertile. The microscope ...

Reference: Kazama K, Miyagoshi Y, Nishizono H. Tle6 deficiency in male mice led to abnormal sperm morphology and reduced sperm motility. Front Cell Dev Biol. 2024;12:1481659. doi: ...

Germ cells in men produce sperm. Testicular germ cell tumours can develop from germ cell neoplasia in situ (GCNIS). GCNIS means that there are abnormal cells in the testicle. The cells look abnormal ...

More information: Kousuke Kazama et al, Tle6 deficiency in male mice led to abnormal sperm morphology and reduced sperm motility, Frontiers in Cell and Developmental Biology (2024). DOI ...

(2) The fertile group showed a significant decrease in seminal lipid peroxidation levels compared to the three abnormal groups ... antioxidants that protect sperm cells against oxidative damages.

Researchers develop a novel Tle6 gene hetero knockout mice model to understand the role of this gene in male fertility and find that its deficiency results in abnormal sperm structure, reduced ...