In this valuable study, Roiuk et al employed a combination of ribosome profiling and reporter assays to provide convincing evidence that eIF2A is not involved in translational regulation in cultured ...

Protein synthesis is vital for life, translating genetic information from DNA to functional proteins through transcription ...

Subsequently, this leads to the formation of 48S preinitiation complex (48S-PIC), which scans the 5′ untranslated region (UTR) of the mRNA and recognizes the start codon (AUG). In the final step, ...

Alterations in the expression and activity of specific translation factors, and the uncoupling of translational regulation from inhibition by tumour cell stresses, such as hypoxia and nutrient ...

Nevertheless, nicking mutagenesis has been rising in popularity for achieving codon-level saturation mutagenesis recently. To sum up, different methods of generating mutation libraries have their own ...

Most saturation mutagenesis uses an NNK codon (where N represents A, T, G or C, and K represents G or T), which yields 32 possible codons to encode 20 amino acids, so 12 of the codons are duplicates.

ViGeneron also received approval for dose escalation in the ongoing phase 1b clinical trial.

Minutes past midnight, on August 15, 1947, the echoes of Mahatma Gandhi ki jai and Bharat Mata ki jai reverberated through the Cannanore (now Kannur) jail where Communist leader A K Gopalan, then 43, ...

A land lease deal between Saint Augustine’s University and the Florida-based real estate firm 50 Plus 1 Sports is stalled pending a review by the North Carolina Attorney General’s office ...

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A molecular mechanism by which phenotypic variation in disease severity occurs is reported by David Buchner and colleagues at the University of Michigan School of Medicine in the August 15 Science ...