Aim: We evaluated a novel treatment for obesity-related renal, an ATP-citrate lyase (ACL) inhibitor, to attenuate ectopic lipid accumulation (ELA) in the kidney and the ensuing inflammation. Materials ...

Analysts at Jefferies have suggested the first-in-class ATP citrate lyase (ACL) inhibitor could achieve peak sales in the region of $2-$3 billion, again depending on a cardiovascular outcomes ...

Nexletol has been approved as an alternative to statins since 2020, becoming the first drug in the ATP citrate lyase (ACL) inhibitor class to reach the market, and was once tipped as a future ...

Chitinase inhibitors are gaining attention as a promising strategy for pest control in agriculture. These inhibitors target chitinases, enzymes that play a crucial role in the growth and ...

Data sources Seven databases were searched in December 2021. Eligibility criteria Observational or interventional studies with self-reported activity (including return to sport) or knee-related ...

Treatment strategies in the management of FH have investigated the potential role of certain additional options, including microsomal transfer protein inhibitors, liver-selective thyroid hormone ...