Their clinical AD data analysis began with a GWAS on a clinical AD cohort in which nearly half of participants had non-European ancestry, the dataset from the National Institute on Aging Genetics of ...

This new cryo-EM structure represents a remarkable advance in our understanding of how human PINK1 is stabilized” said ...

Notably, microglia spatially associated with amyloid plaques exhibited increased expression of TREM2 and ApoE compared to such cells in non-immunized controls, regardless of whether the treatment was ...

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Not the Same. In amyloid-negative people (left) few tangles accumulate over a decade. In amyloid-positives (right), tangles grow faster in women (red) than men (blue). [Courtesy of Gillian Coughlan, ...

Slow the Spread. In the mouse brain, phospho-synuclein pathology (green) accumulates (top) in, from left to right, the motor ...

Dozens of rodents have been generated that model various aspects of ALS, like motor impairment or degeneration of motor neurons. No model recapitulates the human disease perfectly. By organizing ...

Autoimmunity and Alzheimer’s. People with autoimmune disorders in the UCSF (left) and Stanford medical systems (right) were ...

The National Alzheimer’s Coordinating Center unites the collections of the neuropathology cores at 27 NIA-funded AD Research Centers into a single database. It contains records on 13,000 brains, 3,000 ...

SORL1 knockout, knockin, and transgenic mice are now in the Research Models database. The database will be updated as more models become available.