Here, we use a synthetic amphiphile to modulate the membrane mechanical properties of cell-derived vesicles and probe channel activation. Using precise membrane mechanical characterization approaches ...

eLife reviews research in which approaches from the physical sciences are used to provide insights into the properties of biological systems and processes. Learn more about what we review and sign up ...

Why do authors choose the eLife Model? We spoke to Hironori Funabiki at the Rockefeller University to learn his reasons.

Global biodiversity is declining at an unprecedented rate, with agriculture as a major driver. There is mounting evidence that intercropping can increase insect biodiversity while maintaining or ...

As Editor-in-Chief, Behrens is responsible for the editorial direction and vision of the journal, providing leadership to ...

Morphological profiling allows accurate identification of cell types in dense iPSC-derived cultures, allowing its use for quality control and differentiation monitoring.

This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...

Wang et al. presented visual (dot) motion and/or the sound of a walking person and found solid evidence that EEG activity tracks the step rhythm, as well as the gait (2-step cycle) rhythm, with some ...

Long-term potentiation (LTP) is arguably the most compelling cellular model for learning and memory. While the mechanisms underlying the induction of LTP (‘learning’) are well understood, the ...

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and ...

We introduce a random-access parallel (RAP) imaging modality that uses a novel design inspired by a Newtonian telescope to image multiple spatially separated samples without moving parts or robotics.