Ramakrishnan, a distinguished structural biologist and Nobel Laureate in Chemistry (2009), is renowned for his groundbreaking ...

"Using cryo-electron microscopy, we looked at the structure of the ZorAB complex in great detail. We found that it works like a tiny motor powered by protons. This motor helps the bacteria detect ...

This manuscript provides important structural insights into the recognition and degradation of the host tRNA methyltransferase TRMT1 by SARS-CoV-2 protease nsp5 (Mpro). The data provide compelling ...

Mandy Cohen, director of the U.S. Centers for Disease Control and Prevention (CDC), pointed to mRNA as a preferred platform for the shot since vaccines can be developed and distributed quickly.

Thus, TCR stimulation controls selective translational activity through post-transcriptional mechanisms that maintain mRNA in complexes with repressive translational configuration and/or control their ...

Finally, it is also possible that eIF2D is active in re-initiation in a conditional fashion; in particular, upon induction of the integrated stress response that leads to the unavailability of eIF2α, ...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines contain nucleoside-modified synthetic mRNA, encoding the viral spike glycoprotein. Current COVID-19 mRNA vaccines, BNT162b2 ...

Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, ...

When scientists first began to sequence the DNA of tumours ... s National Institute for Health and Care Research. Indeed, mRNA-4157 (V940) was given alongside the current standard of care ...

Rachubinski and colleagues provide an important manuscript that includes two major advances in understanding immune dysregulation in a large cohort of individuals with Down syndrome. The work ...