During translation, ribosomes can pause on the nucleic acid. Researchers showed that collisions from incoming proteins get ...

Researchers developed a technique to gain a deeper understanding of ribosome function and their cooperative behaviors.

Researchers developed a microscopy technique to observe ribosomes translating mRNA in real time. They found that ribosomes ...

Protein synthesis is vital for life, translating genetic information from DNA to functional proteins through transcription ...

A novel microscopy method has been created by researchers from the Tanenbaum group at the Hubrecht Institute to view the ...

A new imaging technique reveals ribosomes work together when translating mRNA, preventing slowdowns in protein production. This discovery challenges prior beliefs and could revolutionize our ...

引言在我们体内，数以亿计的细胞每天都在进行着极其复杂的生命活动，其中翻译过程扮演着至关重要的角色。翻译是基因表达的最后一步，它通过核糖体（ribosome）将mRNA上的遗传信息转化为蛋白质，驱动细胞的功能。然而，尽管翻译过程已经被广泛研究，研究人员 ...

来自Hubrecht研究所Tanenbaum小组的科学家们开发出一种先进的显微镜技术来观察活细胞内的核糖体。这种方法使研究人员能够跟踪单个核糖体将mRNA转化为蛋白质的过程。他们的研究发现了一个令人惊讶的现象：当核糖体遇到障碍时，它们会相互帮助，这一过程被他们称为“核糖体合作”。这些发现发表于1月31日的《Cell》杂志上，为蛋白质合成提供了新的见解，并为科学家们更密切地研究mRNA翻译提供了有力 ...

with complementary sequences in the ribosome-bound mRNA. Assembly of functional ribosomal subunits is aided by dedicated assembly factors. Here, the authors show that the Reh1 is positioned in the ...

For decades, scientists have tried to stop cancer by disabling the mutated proteins that are found in tumors. But many ...

All three studies concluded that short spacings between RNAP and the ribosome, either directed by the mRNA or by adding a drug to halt RNAP, form expressomes that resemble an earlier lower-resolution ...