(Ursodiol [Urso] is a prescription medication that’s also known as ursodeoxycholic acid ... as metabolism and production of bile acid. By Ocaliva’s mechanism of action, FXR reduces how ...

Now, in a stunning reversal, Advanz has won a reprieve after the General Court of the European Union ordered a suspension of the EC's decision, meaning the license for Ocaliva (obeticholic acid ...

That leaves patients with limited second-line options for treatment if they fail to respond to or cannot tolerate ursodeoxycholic acid (UDCA ... [it] has a different mechanism of action from ...

Primary Biliary Cholangitis Clinical Trial Pipeline Pharmaceutical companies are advancing the Primary Biliary Cholangitis treatment pipeli ...

Licensed therapies include ursodeoxycholic acid (UDCA) and obeticholic acid (OCA), alongside experimental new and re-purposed agents. Disease management focuses on initiation of UDCA for all patients ...

Bile reflux gastritis (BRG) is a gastro-intestinal condition especially characterized by the reflux of bile into the stomach, further leading to mucosal inflammation along with various other clinical ...

The catalytic site of chymotrypsin contains an interior aspartic acid hydrogen-bonded to a histidine which in its turn is hydrogen-bonded to a serine. Polarization of the system due to the buried ...

Thereafter, diammonium glycyrrhizinate and ursodeoxycholic acid were regularly administered ... with a maximum diameter of 5 cm. We believe that the mechanism of portal hypertension secondary to ...

Uric acid is a waste product found in urine. If your body makes too much or doesn't eliminate enough of it, uric acid levels can become too high—a condition known as hyperuricemia. High uric acid ...

Objective: This study aimed to explore the effects of SY-009 on plasma metabolomics in patients with T2DM and the potential metabolic regulatory mechanism ... acid (CDCA), glycochenodeoxycholic acid ...

Dietary measures and medications may help reduce uric acid and manage gout. Gout can occur when blood uric acid levels are too high, causing crystals to form in the toes, feet, and other joints.

Davies, R. E., Biochem. J., 40, Proc. xxxv (1946). Davies, R. E., and Longmuir, N. M., Proc. Biochem. Soc. (1946).