Oxidative DNA injury is associated with commitment to apoptosis as indicated by caspase-3 expression and TUNEL positivity. The highly significant association between 8-OHdG and caspase-3 ...
Activation of caspase 3 and PARP cleavage, by western blot and immunohistochemistry, and DNA fragmentation, by gel electrophoresis and TUNEL, are frequently used as apoptosis assays in vivo.
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