T-cell exhaustion, characterized by the overexpression of immune checkpoint molecules, contributes to osteosarcoma progression and immune evasion. Although targeting these inhibitory pathways has ...

A different picture emerges in the context of chronic infection or cancer where the persistence of Ags and inflammation lead to a state of T cell exhaustion. In the second part of this review, we will ...

The potential impact of this form of therapy in pediatric precursor B-lineage acute lymphoblastic leukemia (pre-B ALL) has yet to be determined. Mabs directed against the cell surface antigens ...

Many people often struggle with energy levels due to factors like poor nutrition, high stress, and sleep deprivation. Foods ...

Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in preclinical models tested in mice.

Abstract Research of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia (FM), two acquired chronic illnesses affecting mainly females, has failed to ascertain their frequent ...

This symptom can also be accompanied by acute chest syndrome.” Fatigue: As sickle cells cannot carry oxygen properly, chronic fatigue is mostly present. Lower respiratory tract infections (LRTIs ...

Pre-workouts are popular supplements that claim to boost performance, but do they work? A registered dietitian explains.

“I don’t think superhero fatigue is a real thing, but I do think that the genre of superhero storytelling has become so ubiquitous that it’s gotten to a point where it’s not fresh and it ...

Jan. 23, 2025 — There's a downside to being a powerful alpha male -- at least if you're a baboon. Studies show that despite their high rank, the No. 1 males in baboon society are also some of ...