The team examined two series of different markers on the various proteins ... if the immune cells resume normal function. If CD8 + T cell exhaustion can be reversed, the next question is whether ...

Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the way for improved immunotherapies.

Persistent antigen stimulation, as observed in cancer and chronic infections, leads to T cell exhaustion (TEX), a state of impaired effector functions. Typically, TEX has been characterized by ...