Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the way for improved immunotherapies.

However, T cell exhaustion during HIV infection may be mediated by a mechanism beyond the GAS5 ... Sample preparation and surface and intracellular marker staining were performed using the following ...

Research led by the Chiba Cancer Center Research Institute in Japan has discovered a surprising way cancer evades the immune system. It essentially hacks the immune cells, transferring its own faulty ...

Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its frontline defenders—T cells—lose their ability to function effectively.

CD8 + T cell exhaustion is defined by a unique transcriptional and epigenetic profile that is important to understand for the generation of immunotherapies to treat cancer. Research now shows how ...

Data from clinical studies suggest that complications of trauma are associated with immunosuppressive purinergic responses and elements of CD8 T cell exhaustion, characterised by increases in ...

Like for HIV, lymphopenia and drastic reduction of CD4+ T cell counts in COVID-19 patients have been linked with poor clinical outcome. As CD4+ T cells play a critical role in orchestrating responses ...

Our findings also highlight that HBcrAg might be a better viral marker than HBsAg to discriminate hepatitis B e antigen negative patients with preserved HBV-specific (CD4 +) T cell responses and thus ...

Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its frontline defenders - T cells - lose their ability to function effectively. The ...

Scientists mapped how the human immune system evolves from birth to old age, revealing key changes that influence health, ...