Department of Chemistry, Faculty of Philosophy, Science and Letters at Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-901, São Paulo, Brazil ...

SLC25A1 drives citrate export from the mitochondria to the cytosol, where it fuels acetyl-CoA synthesis by ATP citrate lyase (ACLY). This acetyl-CoA supply sustains FSP1 acetylation and prevents its ...

Aromatase is an enzyme that converts testosterone to estradiol, a type of estrogen. One study found that taking an estrogen blocker called an aromatase inhibitor while on testosterone therapy reduced ...

You can use the Krita plugin with your custom installation of ComfyUI. When connecting it will check for a number of custom node extensions and models which it ...

Quercetin is a flavonoid present in many fruits, vegetables, and grains, recognized for its antioxidant and anti-inflammatory properties. Studies have explored the possibility of this nutrient ...

Clinical trials are now underway to test ACLY inhibitors for treating various cancers and metabolic disorders. A new target for anti-ageing interventions? Could targeting ACLY be a way to slow ...

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China Department of Medicinal Chemistry, School ...

A series of assays were conducted to examine the effects of ACLY on the proliferation and migration of CCA cells. Ferroptosis inducers and inhibitors, along with lipid peroxide probes and MDA assay ...